Sodium Hydroxide → HCID 13607953, compound

Participants

Reaction Steps

A solution of 3-[(4-fluorophenyl)thio]-1-[(4-methylphenyl)sulfonyl]piperidine and excess meta-chloroperoxybenzoic acid in methylene chloride was stirred at room temperature overnight. An excess of sodium sulfite and water was added and the mixture was stirred for 2 hr. An excess of sodium hydroxide was added. The methylene chloride phase was extracted with several portions of dilute aqueous sodium hydroxide, dried over magnesium sulfate and the solvent removed in vacuo to give an oil. The oil was crystallized from a mixture of methylene chloride-diethylether-hexane to give white crystals,

Provenance & Evidence