Imidazole → HCID 23317797, compound

Participants

Reaction Steps

60.7 g (0.188 mol) 2-cyclopentyloxy-2-(2-methylphenyl)-3-methylsulfonyloxy-propanenitrile, 63.9 g (0.938 mol) imidazole and 3.88 ml DMF are stirred for six hours at 160° C. bath temperature. They are then poured into 200 ml water, extracted twice--each time with 200 ml methylene chloride--and the organic phase is then dried with MgSO4. It is then rotated in a vacuum after which the oil is dissolved in 100 ml isopropanol and then reacted dropwise with 10 ml 100% nitric acid, with cooling with ice. Next follows 20 minutes after-stirring with RT, addition of 200 ml acetic ester, and evacuation in a vacuum. In this manner 30.7 g of the title compound are obtained, MP: 160° C. (decomposition).

Provenance & Evidence