Sodium Hydroxide → HCID 178512102, compound

HRID 1981842Notes

Reaction equation

HRID 1981842 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].C[N:11](N=O)[C:12]([NH:14][N+:15]([O-:17])=[O:16])=N.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH:6][C:12]([NH:14][N+:15]([O-:17])=[O:16])=[NH:11]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 668533-FluorobenzylamineHCID 135436526N-Methyl-N'-nitro-N-nitrosoguanidine

Product 1

HCID 178512102HCID 178512102, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound m-fluorobenzylamine (7.5 g, 0.06 mol) is added to a slurry of N-methyl-N-nitroso-N'-nitroguanidine (8.33 g, 0.056 mol) in a 50% aqueous ethanol mixture. The thus-formed mixture is stirred for 18 hours, then treated with 1N NaOH (150 ml), and the mixture filtered. The filtrate is acidified with concentrated HCl, and the reaction mixture is then filtered to obtain the desired fluffy white solid product (10.6 g) having a melting point of 177° C.-179° C.

Workup

  1. filtrationthe mixture filtered
  2. filtrationthe reaction mixture is then filtered

Sources & evidence

ORD record
ord-8b1256da43ce4d7c88baa04dbfb3865a
Source dataset
uspto-grants-1986_06
Patent number
US04594092

Reaction notes

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