HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dimethylpiperazine → Pirenzepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dimethylpiperazine | HCID 7818 | — |
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Pirenzepine | HCID 4848 | 49.1% |
Reaction Steps
A solution of 11-(2-chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (5 g) and N,N'-dimethylpiperazine (4 g) in acetonitrile (100 ml) was heated to reflux for 2 hours. The mixture was evaporated and the residue, crystallized from methanol, yielded 3 g (42.9%) of 11-[2-(4-methylpiperazin-1-yl)-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one N1 -chloromethylate melting at 198°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04594190 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-40acc5e1843f4693a57a9d0559e75357 |
| Source note | uspto-grants-1986_06 |