Sulfuric Acid → HCID 23317882, compound

Participants

Reaction Steps

To a solution of 2.80 g of ethyl 2-acetylthio-3-benzoylpropionate in 30 ml of ethanol was added 4 ml of 10N sulfuric acid, and the mixture was refluxed at heating with stirring for 4 hours. The ethanol was removed from the mixture by evaporation under redused pressure, and diethyl ether was added to the residue. The mixture was washed with water and dried over magnesium sulfate. The diethyl ether was removed from the mixture by evaporation, and the residue was purified by silica gel column chromatography using a mixture of hexane and diethyl ether as an eluent to give 1.62 g of ethyl 3-benzoyl-2-mercaptopropionate as an oil.

Provenance & Evidence