HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine → Fmau
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine | HCID 54100196 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | Fmau | HCID 72327 | 83.3% |
Reaction Steps
1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (150 mg) is dissolved in saturated methanolic ammonia (15 ml), and the mixture left standing for 16 hours. The solvent is removed by evaporation in vacuo, and the residue crystallized from water to give 80 mg of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine, m.p. 185°-185.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04594339 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-96132df5c92049749906da17a2d68cee |
| Source note | uspto-grants-1986_06 |