反应详情

8,9-Difluoro-2-methyl-6-oxo-1,2-dihydro-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (11.5 g) is dissolved in conc. sulfuric acid (120 ml), and thereto is added potassium nitrate (17 g), and the mixture is reacted at an inner temperature of 70° C. for 2 hours. After the reaction, the reaction mixture is added to ice-water (1 liter), and the precipitated crystals are separated by filtration and recrystallized from dimethylformamide to give 8,9-difluoro-2-methyl-7-nitro-6-oxo-1,2-dihydro-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (6.8 g) as white cubic crystals. m.p. 265°-268° C. (decomp.)

1. customthe mixture is reacted at an inner temperature of 70° C. for 2 hours
2. customAfter the reaction
3. customthe precipitated crystals are separated by filtration
4. customrecrystallized from dimethylformamide