HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoate → 3-Methylflavone-8-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoate | HCID 242 | — |
| Reactant | Benzoic anhydride | HCID 7167 | — |
| Reactant | 2-Propionyloxybenzoic acid | HCID 95938 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | HCID 54465964 | HCID 54465964 | — |
| Product | 3-Methylflavone-8-carboxylic acid | HCID 77016 | — |
Reaction Steps
Thus, 2-propionyloxybenzoic acid is heated with anhydrous aluminum chloride in a Fries rearrangement and the resulting 3-carboxy-2-hydroxypropiophenone is heated with benzoic anhydride and alkali benzoate at 180° to 190° C. to afford 3-methylflavone-8-carboxylic acid derivatives.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04594345 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-a777d37c13a04c7ca46c3340f8de3cad |
| Source note | uspto-grants-1986_06 |