HCID 53768474, compound → HCID 18603046, compound

Participants

Reaction Steps

N-t-Butoxycarbonyl-prolyl-phenylalanyl-glycine pentachlorophenyl ester in an amount of 36.4 g was dissolved in 410 ml of 2.2 N HCl-ethyl acetate. A precipitate was produced soon. After the reaction at room temperature for 1.5 hours, the precipitate was filtered, washed with ether and recrystallized from 1.2 l of methanol to give crystals of prolyl-phenylalanyl-glycine pentachlorophenyl ester.hydrochloride in yield of 21.5 g (65.2%) having a melting point of 182°-184° C. and Rf=0.78 (TLC, chloroform: methanol: acetic acid=85:5:3 by volume).

Provenance & Evidence