Potassium Hydroxide → HCID 10791242, compound

Participants

Reaction Steps

A mixture of 5.96 g of (±)-cis-2-(4-methylphenyl)-3-hydroxy-8-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 5.89 g of 2-(N-benzyloxycarbonyl-N-methylamino)ethyl chloride, 1.68 g of potassium hydroxide and 85 ml of dimethylsulfoxide is treated in the same manner as described in Example 1-(1). The crude product thus obtained is purified by silica gel chromatography (solvent, benzene:ethyl acetate=9:1). 7.89 g of (±)-cis-2-(4-methylphenyl)-3-hydroxy-5-[2-(N-benzyloxycarbonyl-N-methylamino)ethyl]-8-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as an oil.

Provenance & Evidence