HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 70495537, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzyl (2-chloroethyl)methylcarbamate | HCID 13592063 | — |
| Reactant | HCID 86740839 | HCID 86740839 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 70495537 | HCID 70495537 | 51% |
Reaction Steps
A mixture of 5 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-8-benzyloxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 3.8 g of 2-(N-benzyloxycarbonyl-N-methylamino)ethyl chloride, 1.1 g of potassium hydroxide and 70 ml of dimethylsulfoxide is treated in the same manner as described in Example 1-(1). 3.75 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-benzyloxycarbonyl-N-methylamino)ethyl]-8-benzyloxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04594342 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-6c7a5ffc55ce420cb8ca378d53f22ea5 |
| Source note | uspto-grants-1986_06 |