HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 10791242, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzyl (2-chloroethyl)methylcarbamate | HCID 13592063 | — |
| Reactant | HCID 67790739 | HCID 67790739 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 10791242 | HCID 10791242 | 79.3% |
Reaction Steps
2 g of (±)-cis-2-(4-methylphenyl)-3-hydroxy-8-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 0.4 g of potassium hydroxide, 15 ml of dimethylsulfoxide and 2.58 g of 2-(N-benzyloxycarbonyl-N-methylamino)ethyl chloride are treated in the same manner as described in Example 1-(1). 2.6 g of (±)-cis-2-(4-methylphenyl)-3-hydroxy-5-[2-(N-benzyloxycarbonyl-N-methylamino)ethyl]-8-methyl-2,3-dihydro-1,5-benzothiazepine-4(5H)-one are obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04594342 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-e8c7dbae09094ff0b170027b2af24da1 |
| Source note | uspto-grants-1986_06 |