trans-Bis(methylammine)dichloroplatinum(II) → Cyclohexane-1(R),2(R)-diamine-platinum(II)

Temperature

60 °C

Dichloro(1,2-diaminocyclohexane)platinum(II) (760 mg) and silver nitrate (680 mg) were stirred in the dark at 50° C. for 3 hours. The reaction mixture was chilled for 24 hours and filtered. An excess of sodium heptafluorobutyrate was added to the filtrate and the reaction mixture was heated at 60° C. A precipitate appeared and this was filtered and washed with water to give the title product (350 mg). The product is insoluble in water but soluble in alcohol (ethanol) to 50 mg/ml. In the TLC system n-butanol:acetic acid:H2O (12:3:5) on cellulose, the product gave an Rf of 0.83 (spotting solvent-ethanol with heptafluorobutyric acid). The IR was consistent for the indicated structure.

1. temperatureThe reaction mixture was chilled for 24 hours
2. filtrationfiltered
3. additionAn excess of sodium heptafluorobutyrate was added to the filtrate
4. filtrationthis was filtered
5. washwashed with water

ORD record

ord-e7cff5556fcd4035b87da3cf717f3681

Source dataset

uspto-grants-1986_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04594418