反应详情

To a solution of aminothiophenol (8.3 g) in methylene chloride at 0° C. is added methyl chloroacetimidate hydrochloride [prepared according to procedures described by R. Roger and D. G. Neilson, Chem. Rev., 61, 179 (1961)] (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water (3X); dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120°-135° C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product.

1. washThe mixture is washed with water (3X)
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated to an oil
4. distillationThe oil is distilled (120°-135° C. at 0.5 mm Hg)