HuagongsheHuagongshe Chemistry Print Report · For research reference only
Perchloric Acid → 7-(2-Methoxyimino-3-oxo-4-bromobutyramido)-3-hydroxycepham-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Perchloric Acid | HCID 24247 | — |
| Reactant | 7-(2-Methoxyimino-3,3-diethoxy-4-bromobutyramido)-3-hydroxycepham-4-carboxylic acid | HCID 86738093 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 7-(2-Methoxyimino-3-oxo-4-bromobutyramido)-3-hydroxycepham-4-carboxylic acid | HCID 86738091 | 43.5% |
Reaction Steps
70% Perchloric acid (3.4 ml) was added to a solution of 7-(2-methoxyimino-3,3-diethoxy-4-bromobutyramido)-3-hydroxycepham-4-carboxylic acid (syn isomer, 5.0 g) in acetone (40 ml) under ice-cooling and stirred at the same temperature for an hour. The precipitates were collected by filtration, washed with acetone (5 ml) twice and dried to give 7-(2-methoxyimino-3-oxo-4-bromobutyramido)-3-hydroxycepham-4-carboxylic acid (syn isomer, 1.85 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04594446 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-9f05e395378b4d5495e07868457008e1 |
| Source note | uspto-grants-1986_06 |