Bromobenzene → HCID 13643796, compound

Participants

Reaction Steps

To a mixture of 66.9 g of N-acetyl-2,4-diethoxyaniline and 70.7 g of bromobenzene, 29 g of anhydrous potassium carbonate, 2.1 g of copper powder and 0.8 g of iodine were added, and the mixture was reacted at a temperature of from 170° to 180° C. for 20 hours. Then, to this reaction mixture, 30 g of potassium hydroxide and 100 ml of isoamylalcohol were added, and the mixture was reacted at a temperature from 120° to 130° C. for 3 hours. Then, 300 ml of toluene was added thereto. The toluene layer was washed with water, separated by liquid separation, concentrated and then purified by distillation under reduced pressure, whereby 54 g of oily N-phenyl-2,4-di-ethoxyaniline was obtained. The boiling point of this product was from 180° to 185° C./3 mmHg.

Provenance & Evidence