Thionyl Chloride → HCID 23317233, compound

Participants

Reaction Steps

A solution of 1 g of 8-chloro-1-methyl-3-hydroxy-6-phenyl-1,2,3,4-tetrahydro-1,5-benzodiazocine in 50 ml benzene was heated under reflux for 1 hour with 1 ml thionylchloride. The solution was reacted with a few drops of triethylamine, washed with water and concentrated by evaporation to dryness in a vacuum. The residue was dissolved in isopropanol and reacted with an ether solution of hydrogen chloride. There was obtained 7-chloro-1-methyl-2-chloromethyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine hydrochloride. The product was also identical with the product obtained in Example 10 of application Ser. No. 335,986; m.p. 110°-112° C.

Provenance & Evidence