Phosphorus oxychloride → HCID 178445606, compound

Participants

Reaction Conditions

Reaction Steps

21.0 g of 6-[2-(trans-4-butylcyclohexyl)ethyl]-3(2H)-pyridazinone are treated with 20 ml of phosphorus oxychloride and slowly heated to reflux. After boiling under reflux for 20 minutes, the excess phosphorus oxychloride is distilled off. The residue is cooled 0° C., hydrolyzed cautiously with 100 g of crushed ice, then neutralized with sodium hydrogen carbonate and extracted three times with 100 ml of tert.butyl methyl ether each time. The combined organic phases are dried over sodium sulphate and freed from solvent on a rotary evaporator. The crude product of 3-chloro-6-[2-(trans-4-butylcyclohexyl)ethyl]pyridazine obtained is recrystallized from ethanol.

Provenance & Evidence