Methyl chloroacetate → HCID 23317380, compound

Participants

Reaction Conditions

Reaction Steps

To 188 ml of dimethyl sulfoxide was added 54.2 g of potassium p-vinylbenzenesulfinate, and the resulting mixture was stirred while heating at 50° C. Then, 23.0 ml of methyl chloroacetate was added dropwise to the mixture over 1 hour while maintaining it at 50° C., and the resulting mixture was stirred for 1 hour while maintaining at 50° C. The reaction mixture was cooled to room temperature and extracted with ethyl acetate, and the ethyl acetate was distilled away at an outer temperature of not more than 40° C. to yield 60.1 g of oily methyl p-vinylbenzenesulfonylacetate.

Provenance & Evidence