反应详情

146.6 ml (1.57 moles) of phosphorus tribromide are added dropwise to 109.7 g (0.562 mole) of methyl 2-methoxymandelate, while cooling well. After 3 hours stirring at room temperature, the mixture is poured into 3N NaCl solution, and extracted with methylene chloride. After washing the organic phase with water, it is dried with Na2SO4 and is concentrated. 140.7 g of the title compound are obtained as a yellowish oil which is used further without purification.

1. temperaturewhile cooling well
2. extractionextracted with methylene chloride
3. washAfter washing the organic phase with water, it
4. dry with materialis dried with Na2SO4
5. concentrationis concentrated