Iodobenzene → HCID 23317473, compound

Participants

Reaction Steps

2.7 g of 2,3-dihydro-2-(2-methoxyphenyl)benzothiazin-3-one, together with 1.2 g of potassium acetate, 6 g of iodobenzene and copper on an aluminum oxide support as the catalyst, in 80 ml of mesitylene are heated at 160° C. for 6 hours under a water separator which is charged with 2 g of barium oxide and 5 g of silica gel. After filtration, the residue is washed with dilute ammonia, and the filtrate is concentrated and chromatographed on 100 g of silica gel using ispropyl ether. 2.6 g of crude product are obtained, and this crystallizes from isopropyl ether/a little acetone, melting point 133° C.

Provenance & Evidence