Sodium Azide → HCID 15586834, compound

Participants

Reaction Steps

6,7,8-Triacetoxy-1-iodomethyl-3-oxo-2-oxa-4-azabicyclo[3.3.1]nonane (as described in Example 2 of the Japanese Patent Application No. 144309/1981, pp. 39) (4.5 g) is dissolved in dimethylformamide (15 ml), and sodium azide (1.0 g) is added to the solution, followed by stirring under heating on a bath of the temperature of 130° to 140° C. for 2 hours. The reaction mixture is treated in the same manner as described under (a) of Reference Example mentioned above to produce crystalline 6,7,8-triacetoxy-1-azidomethyl-3-oxo-2-oxa-4-azabicyclo[3.3.1]nonane (3.2 g).

Provenance & Evidence