Methyl iodide → HCID 13390866, compound

HRID 1982199Notes

Reaction equation

HRID 1982199 reaction equation
[S:1]1(=[O:11])(=[O:10])[C:5]2=[CH:6][S:7][CH:8]=[C:4]2[C:3](=[S:9])[NH:2]1.[OH-].[Na+].I[CH3:15]>C(O)C.O>[CH3:15][S:9][C:3]1[C:4]2=[CH:8][S:7][CH:6]=[C:5]2[S:1](=[O:10])(=[O:11])[N:2]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 13390867HCID 13390867, compound

Product 1

HCID 13390866HCID 13390866, compoundYield 36.3%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a mixture of 0.9 g (0.0044 mole) of thieno[3,4-d]isothiazol-3(2H)-thione 1,1-dioxide in 4 ml of ethanol is added a solution of 0.35 g (0.0044 mole) of 50% sodium hydroxide in 3 ml of water. To this thick mixture is added 0.62 g (0.0044 mole) of iodomethane. The mixture is heated under reflux for 5 minutes, and then filtered to give 0.35 g of product. On cooling, a second crop of 0.1 g of material is obtained. A small amount of the first crop is recrystallized from ethanol to afford an analytical sample, m.p. 184°-6° C.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 5 minutes
  3. filtrationfiltered

Sources & evidence

ORD record
ord-a48aca44373d4c12a69f8a3b4f878901
Source dataset
uspto-grants-1986_06
Patent number
US04595757

Reaction notes

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