反应详情

To a mixture of 0.9 g (0.0044 mole) of thieno[3,4-d]isothiazol-3(2H)-thione 1,1-dioxide in 4 ml of ethanol is added a solution of 0.35 g (0.0044 mole) of 50% sodium hydroxide in 3 ml of water. To this thick mixture is added 0.62 g (0.0044 mole) of iodomethane. The mixture is heated under reflux for 5 minutes, and then filtered to give 0.35 g of product. On cooling, a second crop of 0.1 g of material is obtained. A small amount of the first crop is recrystallized from ethanol to afford an analytical sample, m.p. 184°-6° C.

1. temperatureThe mixture is heated
2. temperatureunder reflux for 5 minutes
3. filtrationfiltered