3-Amino-4-methoxy-1,2,5-thiadiazole 1-oxide → HCID 23312508, compound

HRID 1982231Notes

Reaction equation

HRID 1982231 reaction equation
CN(CC1N=C(OCCCN)C=CC=1)C.NC1C(OC)=NS(=O)N=1.[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]3[CH2:48]CCC[CH2:44]3)[N:37]=2)=[N:29][S:28](=O)[N:27]=1>>[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]([CH3:44])[CH3:48])[N:37]=2)=[N:29][S:28][N:27]=1

Participants

4

Reactant 3

HCID 159612163-Amino-4-methoxy-1,2,5-thiadiazole 1-oxideHCID 15961340HCID 15961340, compoundHCID 21292013HCID 21292013, compound

Product 1

HCID 23312508HCID 23312508, compound

Procedure

When a methanolic solution of 3-(6-dimethylaminomethyl-2-pyridyloxy)propylamine [prepared according to published United Kingdom Patent Application No. 2,098,988] is reacted with 3-amino-4-methoxy-1,2,5-thiadiazole 1-oxide according to the general procedure described in United Kingdom Patent Application No. 2,067,987 and the resulting 3-amino-4-[3-(6-piperidinomethyl-2-pyridyloxy)propylamino]-1,2,5-thiadiazole 1-oxide is successively reacted by the general procedure described in Example 1, Step A, and then by either Example 1, Step B, or Example 10, the title compound is thereby produced.

Sources & evidence

ORD record
ord-b46471f7acbf41fa8c045498d08404d0
Source dataset
uspto-grants-1986_06
Patent number
US04595758

Reaction notes

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