HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 2-(4-benzyloxyphenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzeneacetic acid, 4-hydroxy-, methyl ester | HCID 518900 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
Reaction Steps
Benzyl ethers may conveniently be used to protect --YH groups. For example, methyl 4-hydroxyphenylacetate (0.2 mol) is heated at reflux with 25 g benzyl chloride (0.2 mol) and 25 g K2CO3 (0.2 mol) in 100 ml ethanol. The product is added to dilute aqueous HCl, extracted with ether, and purified by silica gel chromatography to yield methyl 4-benzyloxyphenylacetate (7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04595690 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-75d9c71f5026420daa8db644de500ed6 |
| Source note | uspto-grants-1986_06 |