HRID1982311

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID280

Carbon dioxide

CO2

结构：CC[C@H](C)[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC

HCID178455902

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)C[C@H](O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC

HCID178455903

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

1 g of Z-Sta-Ile-His-Lys(Boc)-OMe is dissolved in 10 ml of 95% strength MeOH and hydrogenated with 100 mg of Pd-on-carbon (10% pd) with CO2 -absorption until saturation. After filtering off the catalyst and concentrating to dryness there is obtained H-Sta-Ile-His-Lys(Boc)-OMe in the form of amorphous powder, which is directly further processed; Rf (B)=0.32; Rf (I)=0.17.

WORKUP

后处理

filtrationAfter filtering off the catalyst
concentrationconcentrating to dryness there

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c4b8fa79d7c8412ea0c5254942ededcf
来源数据集: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04595677
来源说明: uspto-grants-1986_06

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:28]([NH:30][C@H:31]([C:44]([O:46][CH3:47])=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])=[O:29])[CH2:22][C:23]1[N:27]=[CH:26][NH:25][CH:24]=1)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)=O>CO>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:28]([NH:30][C@H:31]([C:44]([O:46][CH3:47])=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])=[O:29])[CH2:22][C:23]1[N:27]=[CH:26][NH:25][CH:24]=1)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:5])[CH3:6]