Carbon Dioxide → HCID 178455903, compound

HRID 1982311Notes

Reaction equation

HRID 1982311 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:28]([NH:30][C@H:31]([C:44]([O:46][CH3:47])=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])=[O:29])[CH2:22][C:23]1[N:27]=[CH:26][NH:25][CH:24]=1)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)=O>CO>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:28]([NH:30][C@H:31]([C:44]([O:46][CH3:47])=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])=[O:29])[CH2:22][C:23]1[N:27]=[CH:26][NH:25][CH:24]=1)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 178455902Z-Sta-Ile-His-Lys(Boc)-OMe

Product 1

HCID 178455903HCID 178455903, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g of Z-Sta-Ile-His-Lys(Boc)-OMe is dissolved in 10 ml of 95% strength MeOH and hydrogenated with 100 mg of Pd-on-carbon (10% pd) with CO2 -absorption until saturation. After filtering off the catalyst and concentrating to dryness there is obtained H-Sta-Ile-His-Lys(Boc)-OMe in the form of amorphous powder, which is directly further processed; Rf (B)=0.32; Rf (I)=0.17.

Workup

  1. filtrationAfter filtering off the catalyst
  2. concentrationconcentrating to dryness there

Sources & evidence

ORD record
ord-c4b8fa79d7c8412ea0c5254942ededcf
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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