HCID 178418361, compound → HCID 178455901, compound

Participants

Reaction Steps

145 mg of Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-OMe (Example 4) are dissolved in 2.5 ml of 95% strength MeOH and, after the addition of 15 mg of Pd-on-carbon, hydrogenated by passing hydrogen through and stirring with a small magnetic rod until the starting material has disappeared completely (according to thin layer chromatography monitoring). The whole is filtered, the filtrate is concentrated to dryness, dissolved in 3 ml of H2O and lyophilised, yielding H-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-OMe; Rf (D)=0.32; Rf (M)=0.25; Rf (N)=0.3.

Provenance & Evidence