HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Z-Sta-Ala-Sta-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | H-Sta-OMe | HCID 13384495 | — |
| Reactant | Z-Sta-Ala-OH | HCID 131714737 | — |
| Solvent | Water | HCID 962 | — |
| Product | Z-Sta-Ala-Sta-OMe | HCID 131714738 | — |
Reaction Steps
In a manner analogous to that described in stage 13.1, using as starting materials 150 mg of H-Sta-OMe×HCl (from stage 13.4), 253 mg of Z-Sta-Ala-OH (from stage 13.2), 102 mg of HOBt×H2O, 67 mg of N-methylmorpholine and 178 mg of DCCI, Z-Sta-Ala-Sta-OMe is obtained; Rf (chloroform/methanol ]9:1])=0.37.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04595677 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-67a045b688a746b0897f76661b8b4945 |
| Source note | uspto-grants-1986_06 |