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HRID1982325

反应详情

EQUATION

反应方程式

HRID 1982325 的结构方程式

REACTANTS

反应物

2
结构：O=C=O
HCID280

Carbon dioxide

CO2

2 次

结构：COC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
HCID131714738

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@@H](N)CC(C)C
HCID13384503

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

259 mg of Z-Sta-Ala-Sta-OMe (from stage 13.5) dissolved in 10 ml of 90% strength methanol are hydrogenated in the presence of 30 mg of palladium-on-carbon catalyst (10% Pd) at 25° under normal pressure with CO2 -absorption (CO2 from the removal of the Z-protecting group) until saturation. The catalyst is filtered off, the filtrate is concentrated by evaporation and the residue is dried in a high vacuum. H-Sta-Ala-Sta-OMe is obtained in the form of a colourless foam; Rf (chloroform/methanol/ammonia [40:10:1])=0.41; Rf (C)=0.29.

WORKUP

后处理

  1. customfrom the removal of the Z-protecting group) until saturation
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated by evaporation
  4. customthe residue is dried in a high vacuum