Carbon Dioxide → HCID 178500730, compound

Participants

Reaction Steps

125 mg of Z-Pro-Phe-His-Sta-Ala-Sta-OMe (from Example 13), dissolved in 10 ml of 90% strength methanol, are hydrogenated in the presence of 30 mg of palladium-on-carbon catalyst (10% Pd) at 25° under normal pressure with CO2 -absorption (CO2 from the removal of the Z-protecting group) until saturation. The catalyst is then filtered off, the filtrate is concentrated by evaporation and the residue is dried in a high vacuum. H-Pro-Phe-His-Sta-Ala-Sta-OMe (cf. Example 9) is obtained in the form of a colourless foam; Rf (G)=0.12.

Provenance & Evidence