Carbon Dioxide → HCID 178484730, compound

HRID 1982329Notes

Reaction equation

HRID 1982329 reaction equation
[N:1](C(OCC1C=CC=CC=1)=O)([CH2:3][C:4]([NH:6][C@H:7]([C:14]([NH:16][C@H:17]([C:30]([O:32][CH3:33])=[O:31])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[O:15])[CH2:8][C:9]1[N:13]=[CH:12][NH:11][CH:10]=1)=[O:5])[CH3:2].C(=O)=O>CO>[NH:1]([CH2:3][C:4]([NH:6][C@H:7]([C:14]([NH:16][C@H:17]([C:30]([O:32][CH3:33])=[O:31])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[O:15])[CH2:8][C:9]1[N:13]=[CH:12][NH:11][CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 178501446HCID 178501446, compound

Product 1

HCID 178484730HCID 178484730, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

390 mg of Z-Sar-His-Lys(Boc)-OMe are dissolved in 10 ml of 95% strength MeOH and, after the addition of 40 mg of Pd-on-carbon, hydrogenated with CO2 -absorption until saturation. The catalyst is filtered off, the filtrate is concentrated to dryness and the amorphous residue is dried to constant weight in a high vacuum at 40°, yielding H-Sar-His-Lys(Boc)-OMe; Rf (G)=0.1; Rf (E)=0.25.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to dryness
  3. customthe amorphous residue is dried to constant weight in a high vacuum at 40°

Sources & evidence

ORD record
ord-598af98a228a44b7a2c7b285458edacb
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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