HCID 178418361, compound → HCID 178501443, compound

Participants

Reaction Steps

100 mg of Z-Arg-Arg-Pro-Phe-His-Sta-Sar-His-Lys(Boc)-OMe (see Example 16) are dissolved in 2 ml of 95% strength MeOH and, after the addition of 10 mg of Pd-on-carbon (10% Pd), hydrogenated by passing hydrogen through until the starting material has disappeared completely (monitoring by thin layer ohromatography). The catalyst is filtered off, the filtrate is concentrated to dryness and the residue is dissolved in 2 ml of H2O and lyophilised, yielding H-Arg-Arg-Pro-Phe-His-Sta-Sar-His-Lys(Boc)-OMe; Rf (D)=0.15; Rf (M)=0.25; Rf (O)=0.22.

Provenance & Evidence