Carbon Dioxide → HCID 178445942, compound

HRID 1982340Notes

Reaction equation

HRID 1982340 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([NH:17][C@H:18]([C:25]([NH2:27])=[O:26])[CH2:19][C:20]1[N:24]=[CH:23][NH:22][CH:21]=1)=[O:16])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)=O>CO>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([NH:17][C@H:18]([C:25]([NH2:27])=[O:26])[CH2:19][C:20]1[N:24]=[CH:23][NH:22][CH:21]=1)=[O:16])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 178446039HCID 178446039, compound

Product 1

HCID 178445942HCID 178445942, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

240 mg of Z-Sta-β-Ala-His-NH2 are hydrogenated in 10 ml of 95% strength methanol with 50 mg of Pd-on-carbon (10% Pd) with CO2 -absorption until saturation. The catalyst is filtered off, the filtrate is concentrated to dryness and the solid amorphous residue is pulverised and then dried in a high vacuum, yielding H-Sta-β-Ala-His-NH2 ; Rf (E)=0.11; Rf (M)=0.26.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to dryness
  3. customdried in a high vacuum

Sources & evidence

ORD record
ord-00765dca746b4fbfb84591f84c6e1a55
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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