H-Leu-Gly-OEt.HCl → HS-Leu-Ala-Gly-OC2H5

HRID 1982356Notes

Reaction equation

HRID 1982356 reaction equation
[SH:1][NH:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([NH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:17])[CH2:12]C(C)C)=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].Cl.C(OC(=O)CNC(=O)[C@H](C)N)C.Cl.C(OC(=O)CNC(=O)[C@H](CC(C)C)N)C>>[SH:1][NH:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([NH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:17])[CH3:12])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6]

Participants

4

Reactant 3

HCID 13334684H-Leu-Gly-OEt.HClHCID 14189604L-alanylglycine ethyl ester hydrochlorideHCID 131714519HS-Leu-Leu-Gly-OC2H5

Product 1

HCID 131714520HS-Leu-Ala-Gly-OC2H5

Procedure

This mercaptopeptidyl ester was prepared substantially similarly as HS-Leu-Leu-Gly-OC2H5, above, except that an equivalent amount of L-alanylglycine ethyl ester hydrochloride was used in the coupling reaction instead of L-leucylglycine ethyl ester hydrochloride.

Sources & evidence

ORD record
ord-a90c08edee4e44a3be35703f1736b36a
Source dataset
uspto-grants-1986_06
Patent number
US04596675

Reaction notes

Loading…