Ethanol → 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid ethyl ester
Reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17](Cl)=[O:18])=[CH:16][C:3]1=2.[CH2:20]([OH:22])[CH3:21]>>[CH2:20]([O:22][C:17]([C:15]1[CH:14]=[CH:13][C:4]2[O:5][CH2:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:2](=[O:1])[C:3]=2[CH:16]=1)=[O:18])[CH3:21]Participants
Procedure
Next, 30.44 g of oxepincarboxylic acid III obtained above was allowed to react with 30 ml of thionyl chloride in 200 ml of toluene by heating under reflux for one hour. Concentration of the reaction mixture to dryness under reduced pressure gave 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid chloride IV in a quantitative yield. One half of this acid chloride IV was added to 300 ml of ethanol, and the mixture was stirred at room temperature for three hours and concentrated under reduced pressure. The residue was dissolved in chloroform, and the solution was washed with a saturated aqueous solution of sodium bicarbonate, dehydrated and concentrated to dryness to obtain 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid ethyl ester V in a quantitative yield. Recrystallization from n-hexane gave pure crystals having a melting point of 104°-105° C. IR spectrum (KBr tablet, cm-1): 2980, 1710, 1650, 1610, 1250, 1010.
Workup
- concentrationconcentrated under reduced pressure
- dissolutionThe residue was dissolved in chloroform
- washthe solution was washed with a saturated aqueous solution of sodium bicarbonate
- concentrationconcentrated to dryness
Sources & evidence
- ORD record
- ord-9d0ce38ce1be440b934972a3162e1abf
- Source dataset
- uspto-grants-1986_06
- Patent number
- US04596804
Reaction notes
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