Sodium Hydroxide → HCID 70470762, compound

Participants

Reaction Steps

A mixture of 3.66 g of 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester (compound 1) and 0.44 g of sodium hydroxide in 100 ml of 50% aqueous methanol was heated under reflux for one hour. The reaction mixture was concentrated to dryness to obtain 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid sodium salt as residue. This product was subjected to column chromatography on silica gel using methanol:acetic acid (100:3 v/v) as eluent. Then, the main fraction was concentrated to dryness, and the residue was triturated in dichloromethane to obtain 4.10 g of 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid diacetate/dihydrate (compound 3) (yield: 83.0%)

Provenance & Evidence