Sodium Sulfite → HCID 23316360, compound

Participants

Reaction Steps

To a solution of 2.5 g of methyl 1-(2-nitrobenzyl)pyrrole-2-carboxylate in 50 mL of dry tetrahydrofuran is added 1.54 g of N-chlorosuccinimide. The reaction is allowed to stir at room temperature for 48 hours. To the reaction mixture is added sodium sulfite, the reaction is stirred for an additional 1 hour, filtered and evaporated to dryness. The residue is extracted into 200 mL of ether, the extract is dried over anhydrous magnesium sulfate and evaporated to dryness to yield methyl 1-(2-nitrobenzyl)-5-chloropyrrole-2-carboxylate which is used in the next step without further purification.

Provenance & Evidence