HCID 23316360, compound → HCID 23316354, compound

Participants

Reaction Steps

To a stirred solution of 2.68 g of methyl 1-(2-nitrobenzyl)-5-chloropyrrole-2-carboxylate in 30 mL of anhydrous tetrahydrofuran is added 35 mL of titanium trichloride in a dropwise manner over a 15 minute period. The reaction is allowed to stir at room temperature for 18 hours and then is diluted with 150 mL of a 1:1 mixture of diethyl ether and water. The organic phase is separated, washed with brine and saturated sodium bicarbonate, dried over anhydrous sodium sulfate, and evaporated to dryness to yield methyl 1-(2-aminobenzyl)-5-chloropyrrole-2-carboxylate which is used in the next step without further purification.

Provenance & Evidence