1H-1,2,4-Triazole → HCID 13391184, compound

Participants

Reaction Steps

16 g of crude 2-(2-bromo-thien-5-yl)-2-(4-chlorophenoxymethyl)-oxirane in 200 ml of acetonitrile are heated under reflux with 11 g (0.157 mol) of 1,2,4-triazole and 5 g of potassium carbonate for 4 hours. Thereafter, the reaction mixture is poured onto water, and extracted with methylene chloride. The methylene chloride phase is dried over sodium sulphate and evaporated down in vacuo. The residue is chromatographed over silica gel using the chloroform/ethyl acetate (1:1) system. 10.5 g (55% of theory) of 2-(2-bromo-thien-5-yl)-1-(4-chlorophenoxy)-3-(1,2,4-triazol-1-yl)-propan-2-ol are obtained in the form of a yellow resin which crystallizes after standing for a long time. Melting point 108°-112° C.

Provenance & Evidence