1-Benzylpiperazine → HCID 53891782, compound

HRID 1982500Notes

Reaction equation

HRID 1982500 reaction equation
O.[C:2]([O:6][C:7]([NH:9][C@H:10]([C:15]([OH:17])=O)[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])([CH3:5])([CH3:4])[CH3:3].[CH2:18]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([N:25]1[CH2:30][CH2:29][N:28]([C:15]([C@@H:10]([NH:9][C:7](=[O:8])[O:6][C:2]([CH3:3])([CH3:4])[CH3:5])[CH2:11][CH:12]([CH3:13])[CH3:14])=[O:17])[CH2:27][CH2:26]1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 12373896N-Boc-L-Leucine Hydrate

Product 1

HCID 53891782HCID 53891782, compoundYield 58%

Procedure

Tert-butoxycarbonyl-L-leucine monohydrate (8.92 g) and 1-benzylpiperazine (6.30 g) were condensed in the same manner as in the preparation of tert-butyl (s)-1-(4-diphenylmethylpiperazine-1-yl carbonyl)-3-methyl butylcarbamate to yield 8.06 g of tert-butyl (s)-1-(4-benzylpiperazine-1-yl carbonyl)-3-methylbutylcarbamate as a colorless amorphous substance (yield: 58%).

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-53e4663408ef4f1fa7f12fa1d3991a40
Source dataset
uspto-grants-1986_06
Patent number
US04596803

Reaction notes

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