huagongshe.com
HRID1982503

反应详情

EQUATION

反应方程式

HRID 1982503 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)[C@@H]1O[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCN(Cc2ccc(OC)c(OC)c2OC)CC1
HCID6917749

Ethyl (2R,3R)-3-{[(2S)-4-methyl-1-oxo-1-{4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl}pentan-2-yl]carbamoyl}oxirane-2-carboxylate

C26H39N3O8

结构：CCO.[Na+].[OH-]
HCID23692425

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CN2CCN(C(=O)[C@H](CC(C)C)NC(=O)[C@@H]3O[C@H]3C(=O)[O-])CC2)c(OC)c1OC.[Na+]
HCID23700901

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Under cooling with ice, a 0.48N sodium hydroxide-ethanol solution (9.48 ml) was added to an ethanol solution (20 ml) of ethyl trans-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)piperazine-1-yl carbonyl}butylcarbamoyl]-oxirane-2-carboxylate (2.38 g) obtained above, and the mixture was stirred at room temperature for 2.5 hours. After removal of ethanol by distillation under reduced pressure, water was added, and any insoluble matters were removed by filtration using sellaite. The filtrate was concentrated and dried under reduced pressure to yield 2.31 g of sodium trans-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)piperazine-1-yl carbonyl}butylcarbamoyl]oxirane-2-carboxylate as a light yellow powder (yield: 98%).

WORKUP

后处理

  1. temperatureUnder cooling with ice
  2. customobtained above, and the mixture
  3. customAfter removal of ethanol
  4. distillationby distillation under reduced pressure, water
  5. additionwas added
  6. customany insoluble matters were removed by filtration
  7. concentrationThe filtrate was concentrated
  8. customdried under reduced pressure