1-(2-Pyrimidinyl)piperazine → HCID 54383233, compound

HRID 1982508Notes

Reaction equation

HRID 1982508 reaction equation
O.[C:2]([O:6][C:7]([NH:9][C@H:10]([C:15]([OH:17])=O)[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])([CH3:5])([CH3:4])[CH3:3].[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.CC(C)C[C@H](NC(=O)OC(C)(C)C)C(N1CCN(C2C=CC=CN=2)CC1)=O>>[CH3:14][CH:12]([CH3:13])[CH2:11][C@H:10]([NH:9][C:7](=[O:8])[O:6][C:2]([CH3:3])([CH3:4])[CH3:5])[C:15]([N:27]1[CH2:28][CH2:29][N:24]([C:19]2[N:18]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:25][CH2:26]1)=[O:17]

Participants

4

Reactant 3

HCID 887471-(2-Pyrimidinyl)piperazineHCID 12373896N-Boc-L-Leucine HydrateHCID 54191163HCID 54191163, compound

Product 1

HCID 54383233HCID 54383233, compoundYield 71%

Procedure

Tert-butoxycarbonyl-L-leucine monohydrate (12.5 g) and 1-(2-pyrimidinyl)piperazine (8.21 g) were condensed in the same manner as employed in the preparation of tertbutyl (s)-3-methyl-1-[4-(2-pyridyl)piperazine-1-yl-carbonyl]-butylcarbamate to yield 13.4 g of tert-butyl (s)-3-methyl-1-[4-(2-pyrimidinyl)piperazine-1-yl carbonyl]butylcarbamate (yield: 71%).

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-408d0480caf64e7890c58f236b2f605b
Source dataset
uspto-grants-1986_06
Patent number
US04596803

Reaction notes

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