反应详情

Under cooling with ice, a 0.47N sodium hydroxide-ethanol solution (4.15 ml) was added to an ethanol solution (7.5 ml) of ethyl (2S,3S)-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)piperazine-1-yl carbonyl}butylcarbamoyl]-oxirane-2-carboxylate (1.04 g), and the mixture was stirred at room temperature for 2.5 hours. After removal of ethanol by distillation under reduced pressure, water was added, and any insoluble matters were removed by filtration. The filtrate was concentrated and dried under reduced pressure to yield 1.00 g of sodium (2S,3S)-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)piperazine-1-yl carbonyl}butylcarbamoyl]-oxirane-2-carboxylate as a light yellow powder (yield: 97%).

1. temperatureUnder cooling with ice
2. customAfter removal of ethanol
3. distillationby distillation under reduced pressure, water
4. additionwas added
5. customany insoluble matters were removed by filtration
6. concentrationThe filtrate was concentrated
7. customdried under reduced pressure