Sodium Hydroxide → HCID 23700905, compound

HRID 1982513Notes

Reaction equation

[CH3:1][CH:2]([CH3:30])[CH2:3][C@H:4]([NH:19][C:20]([C@H:22]1[O:24][C@@H:23]1[C:25]([O:27]CC)=[O:26])=[O:21])[C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:9][CH2:8]1)=[O:6].[OH-].[Na+:32]>>[CH3:1][CH:2]([CH3:30])[CH2:3][C@H:4]([NH:19][C:20]([C@H:22]1[O:24][C@@H:23]1[C:25]([O-:27])=[O:26])=[O:21])[C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[N:14]=[CH:15][CH:16]=[CH:17][N:18]=2)[CH2:9][CH2:8]1)=[O:6].[Na+:32]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 13455644HCID 13455644, compound

Product 1

HCID 23700905HCID 23700905, compound

Procedure

In a manner similar to Example 9, ethyl (2S,3S)-3-[(s)-3-methyl-1-{4-(2-pyrimidinyl)piperazine-1-yl carbonyl}-butylcarbamoyl]oxirane-2-carboxylate was hydrolyzed with sodium hydroxide to yield sodium (2S,3S)-3-[(s)-3-methyl-1-{4-(2-pyrimidinyl)piperazine-1-yl carbonyl}butylcarbamoyl]-oxirane-2-carboxylate.

Sources & evidence

ORD record: ord-3b309b8e28034b33ad33af2da8d0bf85
Source dataset: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04596803

Reaction notes

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