HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 8-(4-Chlorophenyl)-5,6-dihydroimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 4-Chlorophenyl cyclopropyl ketone | HCID 81148 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(4-Chlorophenyl)-5,6-dihydroimidazo[1,2-a]pyridine | HCID 13764023 | — |
Reaction Steps
Combine 25 g (0.14 mol) of 4-chlorophenyl cyclopropyl ketone with 50 g (0.73 mol) of imidazole, and heat to 175° C. for 18 hr. Isolation of the product by column chromatography using 200 g of silica gel and methylene chloride as solvent followed by crystallization from ether affords the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04596872 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-740f9eb4f18f4682a5b4335aad01f15f |
| Source note | uspto-grants-1986_06 |