HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 8-Phenyl-5,6-dihydroimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Cyclopropyl phenyl ketone | HCID 77029 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Phenyl-5,6-dihydroimidazo[1,2-a]pyridine | HCID 13764012 | — |
Reaction Steps
Combine 25 g (0.17 mol) of cyclopropyl phenyl ketone with 50 g (0.73 mol) of imidazole, and heat to 200° C. for 18 hr. Isolation from 200 g of silica gel using methylene chloride, followed by crystallization from ether provides the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04596872 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-4545ff0b998542439203efaef455be6b |
| Source note | uspto-grants-1986_06 |