化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloropropionyl chloride → 2-(1-Chloroethyl)-8-fluoro-4H-3,1-benzoxazin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloropropionyl chloride | HCID 111019 | — |
| 反応物 | 2-Amino-3-fluorobenzoic acid | HCID 586408 | — |
| 生成物 | 2-(1-Chloroethyl)-8-fluoro-4H-3,1-benzoxazin-4-one | HCID 20145691 | — |
反応手順
A mixture was 9.3 g of 2-amino-3-fluoro-benzoic acid and 18,6 ml of α-chloropropionyl chloride was refluxed for 3 hours and excess acid chloride was distilled off. The residue was concentrated under reduced pressure at 70° C. for 2 hours to obtain 2-(1-chloroethyl)-8-fluoro-4H-3,1-benzoxazine-4-one which was used as is for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04596875 |
| 出典データセット | uspto-grants-1986_06 |
| ORD ID | ord-7ed6c5fac1ef4a6ab5082a1e1f29ab2c |
| 出典メモ | uspto-grants-1986_06 |