HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Acetamidothiazole → 2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Acetamidothiazole | HCID 17625 | — |
| Edukt | 2-(1-Chloroethyl)-8-fluoro-4H-3,1-benzoxazin-4-one | HCID 20145691 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | HCID 178418244 | HCID 178418244 | — |
| Produkt | 2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide | HCID 13423086 | 39,2% |
Reaktionsschritte
Using the procedure of Step A of Example 6, a solution of 17 g of N-(2-thiazolyl)-acetamide in 340 ml of tetrahydrofuran, 160 ml of butyllithium-hexane solution and 0.06 moles of the product of Step D in 130 ml of tetrahydrofuran were reacted to obtain 8.7 g of 2-[(2-chloro-1-oxo-propyl)-amino]-β-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide melting towards 170° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04596875 |
| Quelldatensatz | uspto-grants-1986_06 |
| ORD ID | ord-d97f7e7df5ad4573ab57dd2eed6f8765 |
| Quellennotiz | uspto-grants-1986_06 |