HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetamidothiazole → 2-[(2-chloro-1-oxo-pentyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetamidothiazole | HCID 17625 | — |
| Reactant | 4H-3,1-Benzoxazin-4-one, 2-(1-chlorobutyl)-8-(trifluoromethyl)- | HCID 13423080 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | HCID 178418244 | HCID 178418244 | — |
| Product | 2-[(2-chloro-1-oxo-pentyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide | HCID 13423083 | 72.6% |
Reaction Steps
Using the procedure of Step A of Example 6, a solution of 6.94 g of N-(2-thiazolyl)-acetamide in 280 ml of tetrahydrofuran and 70 ml of a butyllithium-hexane solution and a solution of 7.8 g of the product of Step A in 40 ml of tetrahydrofuran were reacted to obtain 8.3 g of 2-[(2-chloro-1-oxo-pentyl)-amino]-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide melting towards 184°-186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04596875 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-ad4de0c22b0247f1a5ac0f63d32f7339 |
| Source note | uspto-grants-1986_06 |