5-Methylthiophene-2-carboxylic acid → HCID 54022822, compound

Participants

Reaction Steps

3.00 g (0.012 mol) of (S)-1,1-dimethylethyl [(2-amino-4-methylpentyl)thio]acetate, 172 g (0.012 mol) 5-methyl-2-thiophene carboxylic acid, 1.64 g (0.012 mol) 1-hydroxybenzotriazole, and 2.50 g (0.012 mol) N,N-dicyclohexylcarbodiimide are reacted according to the procedure for Example 3 to give 0.64 g of (S)-1,1-dimethylethyl [[4-methyl-2-[[[5-methyl-2-thienyl]carbonyl]amino]pentyl]thio]acetate as a crystalline solid, mp 81°-83°; [α]D25 +56.5° (C 0.63, methanol).

Provenance & Evidence